{"iri":"http://lmss.sali.org/R7lCj2dvGu7618ONPPEpJB","id":"R7lCj2dvGu7618ONPPEpJB","label":"Systemic Sclerosis","definition":"Systemic sclerosis (also known as scleroderma) constitutes a spectrum of disease in which thickening of the skin is the clinical hallmark. Raynaud's phenomenon, often medically severe and progressive, is present frequently and may be the peripheral manifestation of a vasospastic abnormality in the heart, lungs, and kidneys. The CREST syndrome (calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia) is a variant that may slowly progress over years to the generalized process, systemic sclerosis.","prefLabels":["Scleroderma"],"altLabels":["Autoimmune Connective Tissue Disorder","Progressive Systemic Sclerosis"],"examples":[],"notes":[],"sources":["https://www.ssa.gov/disability/professionals/bluebook/14.00-Immune-Adult.htm#14_00D3","https://www.ssa.gov/disability/professionals/bluebook/14.00-Immune-Adult.htm#14_04"],"branch":{"iri":"http://lmss.sali.org/R7L5eLIzH0CpOUE74uJvSjL","label":"Legal Entity"},"parents":[{"iri":"http://lmss.sali.org/RBJ0dgV4Z2Xk7aGfJt2nSj7","id":"RBJ0dgV4Z2Xk7aGfJt2nSj7","label":"Immune System Disorders"}],"children":[],"relations":[],"url":"https://lmss.io/tag/R7lCj2dvGu7618ONPPEpJB/","source":{"repo":"sali-legal/LMSS","ref":"3f9ac0c9357b2a971582ae79ede243511d47811d","channel":"pre-release"}}